Selected Publications

S-SCAM is essential for synapse formation.
Wittenmayer N, Petkova-Tuffy A, Borgmeyer M, Lee C, Becker J, Böning A, Kügler S, Rhee JS, Viotti JS, Dresbach T.
Front Cell Neurosci. 2023; 17; DOI: 10.3389/fncel.2023.1182493

The synaptic vesicle protein Mover/TPRG1L is associated with lipid droplets in astrocytes.
Krohn J, Domart F, Do TT, Dresbach T.
GLIA. 2023 1-16; DOI: 10.1002/glia.24452

Nanoscopical analysis reveals an orderly arrangement of the presynaptic scaffold protein Bassoon at the Golgi-apparatus.
Ghelani T, Montenegro-Venegas C, Fejtova A, Dresbach T.
Front Mol Neurosci. 2021; Nov 5; doi: 10.3389/fnmol.2021.744034

Neuroligin-1 mediates presynaptic maturation through brain-derived neurotrophic factor signaling.
Petkova-Tuffy A, Gödecke N, Viotti JS, Korte M, Dresbach T.
BMC Biology  2021 September 27; 19, 215;

Regulation of a subset of release-ready vesicles by the presynaptic protein Mover.
Pofantis E, Neher E, Dresbach T.
Proc. Natl. Acad. Sci. U.S.A. 2021

Differential Effect on Hippocampal Synaptic Facilitation by the Presynaptic Protein Mover.
Viotti JS, Dresbach T.
Front Synaptic Neurosci. 2019 Nov 15; 11:30. doi: 10.3389/fnsyn.2019.00030. eCollection 2019.PMID: 31803042

The Calmodulin Binding Region of the Synaptic Vesicle Protein Mover Is Required for Homomeric Interaction and Presynaptic Targeting.
Akula AK, Zhang X, Viotti JS, Nestvogel D, Rhee JS, Ebrecht R, Reim K, Wouters F, Liepold T, Jahn O, Bogeski I, Dresbach T.
Front Mol Neurosci. 2019 Nov 8; 12:249. doi: 10.3389/fnmol.2019.00249. eCollection 2019.PMID: 31787876

Quantifying the Heterogeneous Distribution of a Synaptic Protein in the Mouse Brain Using Immunofluorescence.
Wallrafen R, Dresbach T, Viotti J
S.J Vis Exp. 2019 Jan 29;(143). doi: 10.3791/58940.PMID: 30774137

The Presynaptic Protein Mover Is Differentially Expressed Across Brain Areas and Synapse Types.
Wallrafen R, Dresbach T.
Front Neuroanat. 2018 Jul 13;12:58. doi: 10.3389/fnana.2018.00058. eCollection 2018.

An Optical Assay for Synyaptic Vesicle Recycling in Cultured Neurons Overexpressing Presynaptic Proteins.
Riemann D, Petkova A, Dresbach T, Wallrafen R.
J Vis Exp. 2018 Jun 26;(136). doi: 10.3791/58043.

The Kohlschütter-Tönz syndrome associated gene Rogdi encodes a novel presynaptic protein.
Riemann D, Wallrafen R, Dresbach T.
Sci Rep. 2017 Nov 17;7(1):15791. doi: 10.1038/s41598-017-16004-1.

Modulation of Presynaptic Release Probability by the Vertebrate-Specific Protein Mover.
Körber C, Horstmann H, Venkataramani V, Herrmannsdörfer F, Kremer T, Kaiser M, Schwenger DB, Ahmed S, Dean C, Dresbach T, Kuner T.
Neuron. 2015 Aug 5;87(3):521-33. doi: 10.1016/j.neuron.2015.07.001. Epub 2015 Jul 23.

Bassoon-disruption slows vesicle replenishment and induces homeostatic plasticity at a CNS synapse.
Mendoza Schulz A, Jing Z, Sánchez Caro JM, Wetzel F, Dresbach T, Strenzke N, Wichmann C, Moser T.
EMBO J. 2014 Mar 3;33(5):512-27. doi: 10.1002/embj.201385887. Epub 2014 Jan 17.

Mover is a homomeric phospho-protein present on synaptic vesicles.
Ahmed S, Wittenmayer N, Kremer T, Hoeber J, Kiran Akula A, Urlaub H, Islinger M, Kirsch J, Dean C, Dresbach T.
PLoS One. 2013 May 28;8(5):e63474. doi: 10.1371/journal.pone.0063474. Print 2013.

Neuronal profilin isoforms are addressed by different signalling pathways.
Murk K, Wittenmayer N, Michaelsen-Preusse K, Dresbach T, Schoenenberger CA, Korte M, Jockusch BM, Rothkegel M.
PLoS One. 2012;7(3):e34167. doi: 10.1371/journal.pone.0034167. Epub 2012 Mar 28.

STED nanoscopy with mass-produced laser diodes.
Schrof S, Staudt T, Rittweger E, Wittenmayer N, Dresbach T, Engelhardt J, Hell SW.
Opt Express. 2011 Apr 25;19(9):8066-72. doi: 10.1364/OE.19.008066.

Essential cooperation of N-cadherin and neuroligin-1 in the transsynaptic control of vesicle accumulation.
Stan A, Pielarski KN, Brigadski T, Wittenmayer N, Fedorchenko O, Gohla A, Lessmann V, Dresbach T, Gottmann K.
Proc Natl Acad Sci U S A. 2010 Jun 15;107(24):11116-21. doi: 10.1073/pnas.0914233107. Epub 2010 Jun 1.

Postsynaptic Neuroligin1 regulates presynaptic maturation.
Wittenmayer N, Körber C, Liu H, Kremer T, Varoqueaux F, Chapman ER, Brose N, Kuner T, Dresbach T.
Proc Natl Acad Sci U S A. 2009 Aug 11;106(32):13564-9. doi: 10.1073/pnas.0905819106. Epub 2009 Jul 23.

Exchange and redistribution dynamics of the cytoskeleton of the active zone molecule bassoon.
Tsuriel S, Fisher A, Wittenmayer N, Dresbach T, Garner CC, Ziv NE.
J Neurosci. 2009 Jan 14;29(2):351-8. doi: 10.1523/JNEUROSCI.4777-08.2009.

Polarized targeting of neurexins to synapses is regulated by their C-terminal sequences.
Fairless R, Masius H, Rohlmann A, Heupel K, Ahmad M, Reissner C, Dresbach T, Missler M.
J Neurosci. 2008 Nov 26;28(48):12969-81. doi: 10.1523/JNEUROSCI.5294-07.2008.

Molecular architecture of glycinergic synapses.
Dresbach T, Nawrotzki R, Kremer T, Schumacher S, Quinones D, Kluska M, Kuhse J, Kirsch J.
Histochem Cell Biol. 2008 Oct;130(4):617-33. doi: 10.1007/s00418-008-0491-y. Epub 2008 Aug 22. Review.

Investigating interactions mediated by the presynaptic protein bassoon in living cells by Foerster’s resonance energy transfer and fluorescence lifetime imaging microscopy.
Jose M, Nair DK, Altrock WD, Dresbach T, Gundelfinger ED, Zuschratter W.
Biophys J. 2008 Feb 15;94(4):1483-96. Epub 2007 Oct 12.

Mover is a novel vertebrate-specific presynaptic protein with differential distribution at subsets of CNS synapses.
Kremer T, Kempf C, Wittenmayer N, Nawrotzki R, Kuner T, Kirsch J, Dresbach T.
FEBS Lett. 2007 Oct 2;581(24):4727-33. Epub 2007 Sep 6.

Local sharing as a predominant determinant of synaptic matrix molecular dynamics.
Tsuriel S, Geva R, Zamorano P, Dresbach T, Boeckers T, Gundelfinger ED, Garner CC, Ziv NE.
PLoS Biol. 2006 Sep;4(9):e271.

Assembly of active zone precursor vesicles: obligatory trafficking of presynaptic cytomatrix proteins Bassoon and Piccolo via a trans-Golgi compartment.
Dresbach T, Torres V, Wittenmayer N, Altrock WD, Zamorano P, Zuschratter W, Nawrotzki R, Ziv NE, Garner CC, Gundelfinger ED.
J Biol Chem. 2006 Mar 3;281(9):6038-47. Epub 2005 Dec 21.

Neuroligins and neurexins: linking cell adhesion, synapse formation and cognitive function.
Dean C, Dresbach T.
Trends Neurosci. 2006 Jan;29(1):21-9. Epub 2005 Dec 7. Review.

Structurally and functionally unique complexins at retinal ribbon synapses.
Reim K, Wegmeyer H, Brandstätter JH, Xue M, Rosenmund C, Dresbach T, Hofmann K, Brose N.
J Cell Biol. 2005 May 23;169(4):669-80.

C-terminal synaptic targeting elements for postsynaptic density proteins ProSAP1/Shank2 and ProSAP2/Shank3.
Boeckers TM, Liedtke T, Spilker C, Dresbach T, Bockmann J, Kreutz MR, Gundelfinger ED.
J Neurochem. 2005 Feb;92(3):519-24.

Synaptic targeting of neuroligin is independent of neurexin and SAP90/PSD95 binding.
Dresbach T, Neeb A, Meyer G, Gundelfinger ED, Brose N.
Mol Cell Neurosci. 2004 Nov;27(3):227-35.

Postsynaptic density assembly is fundamentally different from presynaptic active zone assembly.
Bresler T, Shapira M, Boeckers T, Dresbach T, Futter M, Garner CC, Rosenblum K, Gundelfinger ED, Ziv NE.
J Neurosci. 2004 Feb 11;24(6):1507-20.

Functional regions of the presynaptic cytomatrix protein bassoon: significance for synaptic targeting and cytomatrix anchoring.
Dresbach T, Hempelmann A, Spilker C, tom Dieck S, Altrock WD, Zuschratter W, Garner CC, Gundelfinger ED.
Mol Cell Neurosci. 2003 Jun;23(2):279-91.

Unitary assembly of presynaptic active zones from Piccolo-Bassoon transport vesicles.
Shapira M, Zhai RG, Dresbach T, Bresler T, Torres VI, Gundelfinger ED, Ziv NE, Garner CC.
Neuron. 2003 Apr 24;38(2):237-52.

Functional inactivation of a fraction of excitatory synapses in mice deficient for the active zone protein bassoon.
Altrock WD, tom Dieck S, Sokolov M, Meyer AC, Sigler A, Brakebusch C, Fässler R, Richter K, Boeckers TM, Potschka H, Brandt C, Löscher W, Grimberg D, Dresbach T, Hempelmann A, Hassan H, Balschun D, Frey JU, Brandstätter JH, Garner CC, Rosenmund C, Gundelfinger ED.
Neuron. 2003 Mar 6;37(5):787-800.

Reversible translocation and activity-dependent localization of the calcium-myristoyl switch protein VILIP-1 to different membrane compartments in living hippocampal neurons.
Spilker C, Dresbach T, Braunewell KH.
J Neurosci. 2002 Sep 1;22(17):7331-9. Erratum in: J Neurosci 2002 Oct 1;22(19):1a.

Mrnp41 (Rae 1p) associates with microtubules in HeLa cells and in neurons.
Kraemer D, Dresbach T, Drenckhahn D.
Eur J Cell Biol. 2001 Dec;80(12):733-40.

The presynaptic cytomatrix of brain synapses.
Dresbach T, Qualmann B, Kessels MM, Garner CC, Gundelfinger ED.
Cell Mol Life Sci. 2001 Jan;58(1):94-116. Review.

Membrane association of presynaptic cytomatrix protein bassoon.
Sanmartí-Vila L, tom Dieck S, Richter K, Altrock W, Zhang L, Volknandt W, Zimmermann H, Garner CC, Gundelfinger ED, Dresbach T.
Biochem Biophys Res Commun. 2000 Aug 18;275(1):43-6.

The X-ray crystal structure of neuronal Sec1 from squid sheds new light on the role of this protein in exocytosis.
Bracher A, Perrakis A, Dresbach T, Betz H, Weissenhorn W.
Structure. 2000 Jul 15;8(7):685-94.

Crystallization and preliminary X-ray analysis of squid neuronal Sec1.
Bracher A, Dresbach T, Betz H, Weissenhorn W.
Acta Crystallogr D Biol Crystallogr. 2000 Apr;56(Pt 4):501-3.

Protein interactions implicated in neurotransmitter release.
el Far O, O’Connor V, Dresbach T, Pellegrini L, DeBello W, Schweizer F, Augustine G, Heuss C, Schäfer T, Charlton MP, Betz H.
J Physiol Paris. 1998 Apr;92(2):129-33. Review.

A neuronal Sec1 homolog regulates neurotransmitter release at the squid giant synapse.
Dresbach T, Burns ME, O’Connor V, DeBello WM, Betz H, Augustine GJ.
J Neurosci. 1998 Apr 15;18(8):2923-32.

Regulation of neurotransmitter release kinetics by NSF.
Schweizer FE, Dresbach T, DeBello WM, O’Connor V, Augustine GJ, Betz H.
Science. 1998 Feb 20;279(5354):1203-6.

Disruption of syntaxin-mediated protein interactions blocks neurotransmitter secretion.
O’Connor V, Heuss C, De Bello WM, Dresbach T, Charlton MP, Hunt JH, Pellegrini LL, Hodel A, Burger MM, Betz H, Augustine GJ, Schäfer T.
Proc Natl Acad Sci U S A. 1997 Oct 28;94(22):12186-91.

Protein-protein interactions in synaptic vesicle exocytosis.
O’Connor V, Pellegrini L, Dresbach T, Bommert K, el Far O, Betz H, DeBello W, Hunt JM, Schweizer F, Augustine G, Charlton MP.
Biochem Soc Trans. 1996 Aug;24(3):666-70.

SNAP-mediated protein-protein interactions essential for neurotransmitter release.
DeBello WM, O’Connor V, Dresbach T, Whiteheart SW, Wang SS, Schweizer FE, Betz H, Rothman JE, Augustine GJ.
Nature. 1995 Feb 16;373(6515):626-30.

Proteins involved in synaptic vesicle docking and fusion.
Burns ME, Beushausen SA, Chin GJ, Tang D, DeBello WM, Dresbach T, O’Connor V, Schweizer FE, Wang SS, Whiteheart SW.
Cold Spring Harb Symp Quant Biol. 1995;60:337-48.